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No cancer signal has appeared in animals, and in one melanoma line it actually lowered VEGF

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Factors responsible for thrombosis include, among others, vessel wall damage or slowed blood flow

found that mice lacking the GLAST gene developed spontaneous retinal ganglion cell (RGC) reduction and optic nerve degenerative changes, suggesting that reduced GLAST expression leading to glutamate excitotoxicity in the retina may be a potential pathogenetic mechanism for glaucoma (69)

Rutin can inhibit the production of histamine, which is a chemical that causes allergic reactions and inflammation