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Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation

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The protective nature of A is also evident in vivo as 5XFAD mice [genetic AD mouse model harboring the 5 most prominent familial AD mutations (Oblak et al., 2021)] have significantly better survival profiles than wild type mice in a model of Salmonella typhirium -induced meningitis, and as APP knockout mice fare worse than do wildtypes (Kumar et al., 2016)

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Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Roth JA, Swisher SG, Walsh GL, Vaporciyan AA, Mehran RJ, Antonoff MB