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This often correlates with reduced caloric intake as appetite suppression takes effect

Many people report feeling more energetic and optimistic after starting treatment

The intensity and type of side effects can vary based on the ingredients in the injection

Explore alternatives to attending GP surgeries for administration, such as local pharmacies or home administration by district nurses

For those with a personal or family history of diabetes, high blood pressure, blood vessel disease, or high blood sugar, semaglutide treatment should always be monitored by a qualified medical professional

However, anecdotal reports from online forums cited in a 2025 systematic review included anxiety and panic attacks, depression and anhedonia, insomnia, heart palpitations, fatigue and weakness, and loss of appetite