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The resultant PABC-substituted MMAE is not a stable intermediate and spontaneously undergoes a 1,6-elimination with a loss of p -iminoquinone methide and carbon dioxide (self-immolation) leaving MMAE as the product

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Therefore, a disc injury classification with three different basic injury types was established considering the grade of destruction of the different disc components based on morphology and injury mechanism (Table 7-1/Fig

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