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doi:10.2337/db22-823-P

M.MukhopadhyayP.MatyasC.TrojnarE.DamadzicR.et al (2024)

Excessive burden of ROS, failure of clearance mechanisms and even lack of antioxidants may lead to the accumulation of ROS and to oxidative stress [40], which are associated with genetic damage and breast cancer onset [61,62,63,64,65]

In turn, MHC class II molecules are recognized by CD4+ T lymphocytes, leading to the release of ILs, stimulation of B lymphocytes, and subsequent production of nAbs, eventually reducing the efficacy of vector re-administration [112]

Indeed the great majority of genes involved in the biosynthesis of aliphatic GSLs ( CYP79F1 , CYP79F2 , CYP83A1 , FMO GS-OX1 , MYB28 , MYB29 , MYB76 ) and indolic GSLs ( CYP79B2 , CYP79B3 , CYP83B1 , MYB34 , MYB122 ) [23] were downregulated, especially at the latest time point (Fig