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Description
Oral delivery produces slower absorption with sustained but lower peak plasma concentrations, while subcutaneous injection creates rapid peaks within 15-30 minutes followed by faster clearance

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes

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The dose escalation protocol successfully minimized these effects compared to immediate high-dose administration

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[DOI] [PubMed] [Google Scholar] 71.Gussak I., Brugada P., Brugada J., Wright R.S., Kopecky S.L., Chaitman B.R., Bjerregaard P
