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Similarly, DNMT1 knockdown promoted senescence and decreased differentiation potentials of MSCs at early passage, whereas DNMT1 overexpression has the opposite effect at late-passage MSCs, suggesting that RB preserves the proliferation and differentiation potential of MSCs by upregulating DNMT1 [65]

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Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models