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Mechanistically, E2F1-mediated CHAC1 upregulation promotes PKM2 SUMOylation enabling PKM2 nuclear translocation or kinase activation (Pan et al., 2024)

Annexin V-PI apoptosis assay was performed following the treatments to assess cell viability (Fig

Mishra S, Srivastava S, Tripathi RD, Govindarajan R, Kuriakose S, Prasad MNV (2006) Phytochelatin synthesis and response of antioxidants during cadmium stress in Bacopa monnieri L.)
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