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Synthetic insulin, for example, has been used for decades to manage diabetes, dramatically improving many lives

Scientists still arent exactly sure why such bacteria produce vitamin B12 when its exceedingly rare for plants or fungi (as in the fungal fruiting bodies which are mushrooms) to use, let alone require, such a vitamin

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However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems

Deficiencies can occur with medical conditions such as atrophic gastritis (which causes thinning of the stomach lining), pernicious anaemia, Crohns disease, celiac disease, lupus, or other immune system disorders and certain medications