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Timosaponin AIII (Tim-AIII), A steroid saponin, can bind to the heat shock protein 90 (HSP90), which further promotes the ubiquitination of GPX4 and thereby degrades GPX4 [279]

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Although these direct antioxidant effects are observable in vitro, their significance in vivo appears limited, stemming from low plasma concentrations of NAC and the prevalence of more abundant endogenous antioxidants such as GSH, ascorbate, and antioxidant enzymes (e.g., SODs, GPs, CAT) [6,38,39]
