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Metformin monotherapy for NSCLC Preclinical studies Metformin has been used as a single agent in in vivo and ex vivo studies and the data obtained in preclinical studies suggested that it had certain anticancer activity (Table I)

Mito Tempo, a targeted antioxidant, reduces oxidative stress in cells by scavenging mitochondrial superoxide, which helps prevent the generation of harmful ROS like cytosolic hydrogen peroxide (79)

Ion-exchange resins

European Food Safety Authority (EFSA) (2007) Introduction of a qualified presumption of safety (QPS) approach for assessment of selected microorganisms referred to EFSA-opinion of the scientific committee

pseudomallei virulence gene expression and inhibits cell to cell spread 15

Moreover, the use of a synthetic derivative of salinomycin (AM5) in breast CSCs induced iron depletion both in vitro and in vivo, mechanistically via the degradation of ferritin within lysosomes, leading to increased ROS production and subsequent selective breast CSCs death via ferroptosis [101]