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Key regulatory hubs include the mTORC1-ATF4 positive feedback loop, which coordinates amino acid flux and synthesis, and the GCN2-eIF2-ATF4 pathway, activated by amino acid deprivation

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FIGURE 1 2 Phytochemical-based nanosystems for gene and tumor microenvironment targeting 2.1 Formulation challenges and delivery strategies While plant-derived drugs such as vincristine, paclitaxel, and docetaxel are established in oncology, they represent only a small fraction of phytochemicals with demonstrated preclinical anticancer activity that have yet to translate into routine clinical use (Figure 1) (Mazumder et al., 2022