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Phosphorylation at Y239/Y240 site enhances STAT3-driven immunosuppressive pathways (e.g., PD-L1 expression) while repressing STAT1-mediated immune surveillance, reducing CD8+T cell infiltration 43

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Tesamorelin is FDA-approved as Egrifta for visceral fat reduction in HIV lipodystrophy, and Sermorelin held a past FDA approval before being discontinued for business reasons