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2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency

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[8] Across the broader published BPC-157 literature spanning gastrointestinal, musculoskeletal, dermal, vascular, and CNS research mortality in BPC-157-treated groups has generally been reported as comparable to vehicle-treated controls, and no consistent pattern of clinical deterioration has been established as a peptide-specific toxicity signal