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The FR + macrophage numbers were also reduced in the liver and spleen of RA rats following MTX therapy, suggesting that MTX suppressed the numbers of activated macrophages both locally (in inflamed joints) and systemically

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The diagnosis of HIT is hampered by the absence of a validated biomarker and relies on the clinical evaluation, specifically, the response to a low histamine diet and reintroduction of restricted foods

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Impact of CDT toxin on human diseases

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Details on both reaction mechanisms were discussed in a review by Lillig and Berndt [34]

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Katsoulotos GP

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