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The proposed mechanisms for GIC are based on the models of lens epithelial cells ex vivo, for examples, using the rat lens epithelial explants and capsular bag cultured ex vivo, DEX is found to enforces the FGF2-induced lens cell proliferation, and cell coverage of the posterior capsules, but not cell elongation

Despite scarce data in relation to oxidative damage in children suffering from konzo, the role of oxidative damage in many other neurologic diseases has been well established 37

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This divergence likely reflects distinct conformational requirements for direct substrate turnover versus protein-mediated electron transfer