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Moderate and severe TBI carries substantially higher risks of long-term disability, including impaired memory, executive function deficits, emotional dysregulation, and increased vulnerability to neurodegenerative disease later in life

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Thomas Lattas invention of the IV itself

Approximately 5 % to 10 % of the fractures occurring are associated with impaired healing, including delayed union or non-union [15]

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In analogy, genetic ablation of HO-1 amplified the development of atherosclerotic lesions and promoted their progression, thus confirming the protective role of HO-1 against atherogenesis (181)