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CrAT deficiency suppressed the residual glucose dependent de novo lipogenesis in ACLY KO cells and abrogated the effect of carnitine supplementation in promoting de novo lipogenesis (Figure 6G, Supplemental Figure 7I)

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What will happen as more research is done and more drugs are developed is that well transition to even more effective medicines, but I don't think theyll get off medicine

The complexity of adipogenesis, involving numerous molecular mechanisms, makes the study of regulators of this process and their potential as anti-obesity medication targets (AOM) particularly valuable

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