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Mitochondrial Dysfunction in Retinal Pigment Epithelium (RPE) Mitochondria are a primary source of ROS and are particularly vulnerable to oxidative stress [54]

In both experimental models and human diabetic subjects, there is an initial metabolic phase that is responsive to metabolic corrections [90, 91]

Dilated cardiomyopathy is more common in: American and English Cocker Spaniels Springer Spaniels Doberman Pinschers Great Danes Boxers German Shepherds Irish Wolfhounds Scottish Deerhounds Newfoundlands Saint Bernards Labrador Retrievers Portuguese Water Dogs Doberman Pinschers and Boxers can inherit a genetic form of dilated cardiomyopathy

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