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doi: 10.1007/978-1-4939-2288-8_9 342 AkmanMMonteleoneCDoronzoGGodelMNapoliFMerliniAet al

Nontoxic, biodegradable hyperbranched poly (-amino ester) s for efficient siRNA delivery and gene silencing

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This large difference means that there is an insurmountable concentration gradient that prohibits extracellular glutathione entering cells

Theoretically, if homocysteine concentrations become extremely low, substrate availability for glutathione synthesis could also be reduced

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