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Enteric nervous system: the bridge between the gut microbiota and neurological disorders

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Given that 70% of Mel and 85% of insulin-stimulated glucose disposal enters the skeletal muscle, the enhancement of insulin sensitivity and glucose balance by MOTS-c may be mediated in this tissue

The CGRP receptor is a drug target for migraine treatment, and CGRP receptor antagonists and antibodies that block CGRP activity in the human brain are clinically available [37]