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[DOI] [PubMed] [Google Scholar] 129.Ning Y., Lu F., Liu Y., Yang S., Wang F., Ji X., He Z

Culture and BioGEE treatment of THP-1 cells THP-1 cells were routinely cultured in T75 tissue culture flasks in RPMI (Sigma) supplemented with 10% fetal bovine serum and 100 U/mL penicillin-streptomycin

The antiangiogenic agent cilengitide (Merck) is a derivative of the RGD peptide [127130]

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The most intriguing mechanism of zinc upon the immune system is however the existing interrelationship among pro-inflammatory cytokines (IL-6)-Metallothioneins (MT)-Nitric Oxide (NO)-PARP-1 taking into account that IL-6 promotes MTmRNA induction, NO is involved in zinc release by MT and PARP-1 (a nuclear enzyme codified by two zinc finger motifs) prevents apoptosis with subsequent cellular genomic stability (Mocchegiani et al