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Those tissue-specific [110] and transgenerational epigenetic actions of GCs are not limited to DNA m but were also found to include histone modifications (acetylation and deacetylation) [111], microRNAs (miRNAs) abundance [112] and chromatin remodelling [113]

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Structural and pharmacology studies emphasise this because different receptor complexes can respond differently to different ligands, and this can influence how strongly appetite related signals are triggered in model systems

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