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doi: 10.1172/JCI163449 69 MorlacchiSSoldaniCViolaASarukhanA

The ongoing development of new XO inhibitors remains critically important due to welldocumented limitations of existing therapies, including adverse effects, the emergence of resistance, interindividual variability in therapeutic responses, and the requirement for high therapeutic doses, as seen with allopurinol

2 ) oxidation of amino acid side chains, one example of which is 4-oxo-histidine

Sutandy FXR, Gner I, Tascher G, Mnch C

& Kunos, G
