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Since both FACS rounds showed improvement in binding affinity for PBP1b, single-yeast staining experiments of 48 randomly selected clones from the two rounds of selections were used to isolate top binders (SI Fig

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, Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)
