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Severe hypokalaemia (low blood potassium) is rare but can develop in some cases, particularly in severe megaloblastic anaemia or in patients taking certain medications such as diuretics

A shingles vaccine has been available to older adults for more than a decade and to those between 50 and 59 years old since 2011

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If orforglipron can be manufactured at scale for a fraction of the cost of injectable alternatives, and if its oral format eliminates the injection barriers that prevent millions from starting therapy, the public health impact could be measured in reduced cardiovascular events, fewer diabetes-related amputations, decreased obesity-related cancer incidence, and extended healthy lifespan across populations

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The results indicated that the addition of adipose-derived stem cells to Dupuytrens myofibroblasts decreased their contraction, leading to a reduction in -smooth muscle actin protein expression, and inhibited their proliferation [83]