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94 In the colonic mucosa of UC patients, one or more of the three ER stress pathways are activated, resulting in unbalanced protein synthesis and abnormal protein folding, which in turn exacerbates the inflammatory response and intestinal barrier disruption of UC
This signal transduction stimulates the expression and activity of enzymes like 17 -hydroxysteroid dehydrogenase, hence promoting testosterone synthesis [31]
Estimates from similar clinics reported prevalence rates of lipedema ranging from 15 to 18.8% (30,31)
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Circulation 115 , 11321146 (2007)
