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Frasca D, Van der Put E, Riley RL, Blomberg BB

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These biologically active compounds can disrupt immune signaling, mitochondrial energy production, gut barrier integrity, neurological regulation, and detoxification pathways

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FEBS Lett 140:310 Worthington MT, Cohn SM, Miller SK, Luo RQ, Berg CL (2001) Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines

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IV administration can deliver doses up to 10 times higher than oral supplements

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[471] observed that sesamol treatment (100 mg/kg per day) for 6 weeks prevented inflammatory response, epithelial barrier dysfunction, and depression-like and anxiety-like behaviors in DSS-induced UC mice via gu the-brain axis

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Kong, X., Feng, D., Mathews, S

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