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247,248 Saturated fatty acids (SFAs) induce mitochondrial depolarization and reduce the number and velocity of motile mitochondria in DRG neurons

By international agreement, standardized methods have been used to characterize these enzyme variants, which differ on the basis of biochemical properties such as kinetic activity, electrophoretic mobility, the Michaelis constant for its substrate glucose-6-phosphate and cofactor NADP, the ability to utilize different substrate analogues, heat stability, and pH optima

10.1038/s41418-022-01028-6 130 TaucherE.MykoliukI.FediukM.Smolle-JuettnerF

By elucidating these mechanisms, researchers can identify novel therapeutic targets and improve treatment strategies for RA

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Cooney C.A., Dave A.A., Wolff G.L

Data from these experiments can provide further evidence of Gyps' therapeutic potential for AMD