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Acknowledgements The authors are grateful to the National Natural Science Foundation of China for financial supports

That part isnt speculative

High serum B12 with functional deficiency or discordant symptoms A high total B12 can coexist with a cellular shortage of the vitamin

Neurology 80 , 225 (2013)

The evidence: Taking melatonin can help people fall asleep about 7 minutes faster, on average, and studies show that its useful for people with jet lag or a sleep disorder called delayed sleep phase syndrome