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This condition, called megaloblastic anemia, devastates endurance performance even in its mild forms
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Therefore, these mechanisms lead to therapeutic resistance in cancer
Because KP is genetic, there is no permanent cure

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The liver is one of the most well-known hypervascular organs and has a high VEGF level compared with other organs 31 , and cancer patients with liver metastasis showed poorer clinical benefit from anti-PD-1 monotherapy in non-small cell lung cancer (NSCLC), melanoma, or kidney cancer 32
