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Table 1: Subtypes of Psoriasis (NIH 2013

Qian Jiao He KY Zi [2021]037)

Clinical trials using sermorelin or similar GHRH analogues report mean fat loss of 24% of total body weight over 1216 weeks, which translates to roughly 23kg for a 90kg individual

However, clinical translation is hindered by low oral bioavailability, limited BBB permeability, and inconsistent pharmacokinetics

On the other hand, compound 22 showed good and promising selectivity for NOX4 (IC 50 of 0.3 M) with no reported activity against NOX1, NOX2, NOX3, and NOX5, as well as against xanthine oxidase or glucose oxidase

They analyzed dozens of experimental and clinical studies, looking at both natural molecules (like NAC, milk thistle, and whey protein) and pharmaceutical approaches (like dimethyl fumarate or bardoxolone)