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In conditions like ME/CFS, researchers have discovered a fascinating and troubling phenomenon: patients often have normal levels of Vitamin B12 in their standard blood tests, but significantly depleted levels of B12 in their cerebrospinal fluid (CSF)

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Honghua Peng, [email protected] These authors have contributed equally to this work This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The Epworth Sleepiness Scale (ESS), Athens Insomnia Scale (AIS), and Pittsburg Sleep Quality Index (PSQI) were used to quantify excessive daytime sleepiness (EDS), insomnia symptoms, and sleep quality, respectively

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