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When noise and ototoxic drugs cause SGN damage, Ca 2+ influx is exacerbated and the intracellular Ca 2+ concentrations increase, thereby initiating the apoptotic program [126]

Figure 4 3.4.2 IFNs SLE is known as an interferon signature disease and the overactivation of the interferon system is closely related to SLE pathogenesis, especially I-IFN, which is elevated before the onset of SLE and closely associated with disease activity and organ involvement (169171)

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Th2 cells are known to produce cytokines, including IL-4, IL-5, and IL-13, and are important in the immune response towards external infections

doi:10.3390/ijms221910253 26 Reily C, Stewart TJ, Renfrow MB, Novak J