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Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

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PMID 9545095

B12 injections are suitable for individuals diagnosed with a vitamin B12 deficiency or who experience symptoms such as low energy, poor concentration, or mood changes

Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before using it

Media inquiries for the embargoed study are directed through JAMA Network communications, with the corresponding author listed as Michael J