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123 Treatment with N-acetylcysteine can also attenuate lung emphysema induced by elastase as depicted in amelioration of airspace enlargements, partial recovery of expiratory flows, and normalization of lung collagen content

Sequences were visualized and corrected using BioEdit v7.2.5 software 53

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Glutathione synthetase deficiency: Is -glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione

Moreover, the observed upregulation of NOS and HIF1 further supports the presence of oxidative and hypoxic stress in lung tissue, both of which contribute to tissue injury and impaired pulmonary function

doi: 10.1182/blood-2015-11-683847 64 SommermeyerDHudecekMKosasihPLGogishviliTMaloneyDGTurtleCJet al