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413 Partial ablation of astrocytes in the prefrontal cortex of healthy rats (by injection of gliotoxin L--aminoadipic acid) resulted in the development of depressive-like behaviours, whereas injection of neurotoxin ibotenate did not have such an effect

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This extraordinary potency difference stems from Dihexas mechanism as an HGF mimetic binding to c-Met receptors, which triggers intracellular signaling cascades distinct from BDNFs TrkB receptor pathway

The proapoptotic effects of Tamoxifen are supported by studies indicating that increased intracellular Ca + and ROS levels can activate various signaling pathways that facilitate the process of eryptosis [394,395,396]

Understanding the interactions at the molecular level will also be beneficial for designing more effective therapeutic strategies that not only target intracellular regeneration but also optimize the surrounding microenvironment to enhance neural recovery