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The critical metabolic compound responsible for facilitating this process is carnitine, a quaternary ammonium compound biologically active in its L isoform (13, 15, 16)

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TMAO Reduces Vascular Tone Endothelial dysfunction is associated with abnormal changes in the vascular tone, which is regulated by the production of at least three vasoactive factors, nitric oxide (NO), prostaglandin I 2 (PGI 2 ), and endothelium-derived hyperpolarization (EDH) [3,58,84,85,86]