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In turn, the former can be generated via three mechanisms, namely, (i) oxidative deamination of alkaline amino acids (lysine, threonine, arginine and proline) by a radical-mediated mechanism

In a linked fashion, our data from immunoblot analysis showed that canagliflozin induces AMPK in a concentration-dependent manner

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Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T (2019) Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids

Many treatment strategies for AF were established, but do not target the underlying causes of AF

[DOI] [PubMed] [Google Scholar] 2.World Health Organization