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R.SarkarS.et al (2018)

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Notice Regarding AOD-9604 Reconstitution: Acetic Water or a similar solvent is recommended for the AOD-9604 product

Mechanism of Action Through careful experimentation, cellular fat accumulation has been associated with increased activity of nicotinamide N-methyltransferase (NNMT)

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation