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It promotes the release of dopamine by stimulating the terminals of nigrostriatal dopaminergic neurons and reduces neuronal reuptake of dopamine, thereby increasing dopamine levels and exerting anti-parkinsonian effects [127]

177,180,183 Although leptin exhibits anti-steatotic properties, it is also implicated in hepatic steatosis and the progression of MAFLD to more advanced stages, including MASH and fibrosis

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition[J] J

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Tuckey RC, Cheng CYS, Slominski AT

In contrast, ovariectomy decreases mRNA expression of Nrf2 and 25 genes involved in Phase II detoxification, including Gsta4 , and the levels of GSTA4 protein in the inner ears