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Additionally, two-year safety data from the STEP 5 trial shows that while gastrointestinal events occurred in 82% of participants at some point during the study, most of these events were concentrated in the initial 6 months, with frequency and severity declining markedly in long-term treatment

Butyrate acts as a positive allosteric modulator of the 5-HT transporter to decrease availability of 5-HT in the ileum