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Description
The microbial metabolite itaconate reduces Th17 differentiation and promotes Treg generation by inhibiting both glycolysis and OXPHOS (173)
Synovial inflammation in osteoarthritis progression
The understanding of the molecular basis of such bioactivities may be required to identify the role of protein carbonyls in the onset of physiological impairments and pathological conditions
Clinical Considerations Isotretinoin is invaluable as a potent systemic therapy for severe acne, offering durable remission and prevention of scarring when used under strict monitoring and counseling protocols
Clin J Am Soc Nephrol 13:13111313 Borges NA, Barros AF, Nakao LS, Dolenga CJ, Fouque D, Mafra D (2016) Protein-bound uremic toxins from gut microbiota and inflammatory markers in chronic kidney disease
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d
