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Conventional drug conjugation methods are either through less precise interchain disulfide Cys or random lysine residue in the antibody components, resulting in a huge product heterogeneity with limited control over the conjugation locations

Van Biesen, W., Lameire, N., Vanholder, R

doi: 10.3109/10715769309056502

Skundric and Lisak, 2003)

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In other words, researchers observed effects across multiple biological processes, including tissue repair, inflammation signaling, blood vessel formation, and gut healing pathways