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Systemic drugs Sorafenib, the first tyrosine kinase inhibitor authorized for the treatment of patients with unresectable HCC, advanced renal cell carcinoma, and differentiated thyroid cancer, 210 has been shown to trigger ferroptosis by inhibiting system xc- and increasing intracellular iron levels

Recent work also suggests HCHO is involved in folate metabolism 13

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However, this aspect of the dataset is still being refined