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HUBERMAN: Need to be considered in light of the fact that they cause big increases in cortisol

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
Howes FW

These factors continuously stimulate the TLR and purinergic receptors (such as P2X7) of surrounding cells, creating a positive feedback loop that allows inflammation to amplify and trigger systemic acute inflammation (108, 109)

Oh, absolutely
