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Modulation of antioxidant enzymes, SIRT1 and NF-B by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma

[DOI] [PubMed] [Google Scholar] 14.Stein, L

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Mechanistically, sulforaphane, by virtue of forming dithiocarbamate through a reaction with thiol groups, can directly interact with DNA binding and the transactivation of NF-B [325]

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Therefore, to explore the link between TNF- and the ROS-dependent mode of cell death, the experimental groups were examined by flow cytometry, which revealed that TPA caused a marked increase in ROS, whereas 200 ng/ml TNF- significantly reversed the increase in ROS (Fig