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Conversely, the mitochondrial damage and calcium homeostasis imbalance triggered by NLRP3 activation further exacerbate mtROS production, creating a positive feedback amplification loop

doi: 10.3389/fnut.2022.821900 246 AshrafRShahNP

Greicius MD, Supekar K, Menon V, Dougherty RF

Mol Pharmaceutics

If you look at the graph above (light blue section to the right) you will see the high amounts of immunoglobulins the newborn receives via colostrum and also see that those amounts are declining to a lower level for mature milk
