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It has been reported that when ferroptosis occurs in neurons, then microglia are activated and release toxic substances including pro-inflammatory factor IL-6, which can cause neuro-inflammation and lead to further brain damage (Tang et al., 2020)

[DOI] [PubMed] [Google Scholar] 24.Ellman G

Moncaster JA, Walsh DT, Gentleman SM, et al

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doi: 10.1016/j.nut.2019.01.007

Antibodies and plasmids The followed antibodies were used: mouse monoclonal anti-PrP 3F4 55 (dilution: 1:100 for IF), mouse monoclonal anti-PrP 6D12 (Wageningen University and Research, dilution: 1:100 for IF), mouse monoclonal anti-PrP 12B2, 100B3, 94B4 (Wageningen University and Research, dilution: 1:100 for IF, 1:1,000 for WB, 1:100 for IHC)