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Avoiding these in ones diet may be a helpful part of improving tolerance to histamine

Pemetrexed Injection Dosage and Administration 2.1 Premedication and Concomitant Medications to Mitigate Toxicity Vitamin Supplementation Initiate folic acid 400 mcg to 1000 mcg orally once daily, beginning 7 days before the first dose of Pemetrexed Injection and continuing until 21 days after the last dose of Pemetrexed Injection [see Warnings and Precautions (5.1)]

This is where further workup becomes important

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GLP-1 agonists slow gastric emptying, which keeps you feeling full longer